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Because HSV-1 targets Nrf2 at its protein level, we speculate that HSV-1 may induce the downregulation of Nrf2 via the UPS
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In transgenic mice, those expressing the human HLA-DR4 allele had higher IFNγ responses and lower titres of anti- Borrelia antibodies than mice expressing the human HLA-DR11 allele, which had higher anti- Borrelia antibody titres but lower IFNγ responses 103
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