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It helps the intestinal endothelium and “promotes enterocyte proliferation, regulates tight junction proteins, suppresses proinflammatory signaling pathways, and confers protection against apoptosis and cellular stresses during normal and pathological conditions” (Perna et al., 2018)

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Additionally, crosslinking density, polymer hydrophobicity, and nanoparticle size distribution are often overlooked variables that critically affect responsiveness and cytotoxicity