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5 Niacinamide is an excipient with a supportive role to the active ingredients: it supports skin comfort (helping the skin tolerate tretinoin's initial adjustment period), helps inhibit the transfer of melanin to skin surface cells (supporting even tone), modulates ceramide production to support the skin barrier, and offers antioxidant support
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Among these, the formulation with dioleoylphosphatidylcholine (DOPC), known for its high membrane fluidity, achieved approximately 95 % encapsulation efficiency and exhibited excellent stability during storage, effectively preventing curcumin degradation (Fig
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