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[21] [22] Clinical significance [edit] Patients with mutations in the GSS gene develop glutathione synthetase (GSS) deficiency, an autosomal recessive disorder

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Mitochondrial DNA (mtDNA), which encodes 13 essential subunits of the electron transport chain (ETC), is particularly susceptible to oxidative stress, resulting in replication errors, point mutations, and large-scale deletions (Kim and Kim, 2018)