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Under persistent ER stress, the blockage of PERK-mediated global translation leads to the activation of IRE1/XBP1 (x-box binding protein 1) and ATF6 pathways, which in turn promotes the expression of various ER chaperones and ERAD mechanical components to enhance protein folding capacity and degrade irreversibly damaged proteins (Sharma et al., 2021)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Lee J.S., Heo J., Libbrecht L., Chu I.S., Kaposi-Novak P., Calvisi D.F., Mikaelyan A., Roberts L.R., Demetris A.J., Sun Z.T., et al
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