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These findings support the relevance of MGBA mechanisms in BD pathophysiology, implicating both immune and metabolic pathways as shown in Table 8, and are conceptually illustrated through the microbiota–immune–metabolic–brain axis model (Figure 6
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And the team experimented with metformin, glimepiride, a sulfonylurea derivative that does not affect AMPK, and BAIBA, on LPS-induced pro-inflammatory cytokine secretion and glucose uptake
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