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Although a direct causal link between NAD+ supplementation and cancer progression has not been proven, experts recommend that patients with an ongoing cancer or a history of cancer only consider NAD+ therapy with clearance from their oncologist
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Activation of the TLR2/MyD88/NF-κB signaling pathway initiates a cascade of genes associated with inflammatory cytokines, such as IL-1β, IL-8, and TNF-α, thereby exacerbating hepatic injury [72]
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