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Multiple pathways of NAD + synthesis have been identified, which are differentially active in tissues and utilize various molecular precursors to ensure maintenance of NAD + homeostasis and counteract NAD + turnover

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The risk of severe GI events is increased by the presence of the following factors: history of peptic ulcer disease or GI bleed, smoking, alcohol usage, concomitant usage of anticoagulants, or oral corticosteroids, older age, and poor general health status