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More recently constitutive activity of expressed MOR was demonstrated using β -chlornaltrexamine ( β -CNA) in HEK293 cells (Burford, et al., 2000) and β -funaltrexamine ( β -FNA) in GH3 cells (Liu, et al., 2001) and using G protein modulation of calcium channel currents in neurons overexpressing MOR (Mahmoud et al., 2010), although it should be noted that the level of constitutive activity that has been detected is relatively small even when MOR was overexpressed
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Future studies should also be focused on evaluating whether genomic, transcriptomic, proteomic, epigenomic, metabolomic, and micro-biomic alterations in the prostate of African American men predispose them to a higher prevalence of chronic prostatitis, as well as prostate tumor progression, metastasis, and recurrence
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