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This was, however, not the case for the E2 metabolites: the abundance of 2- and 4-MeOE2 was still the lowest of all the metabolites and similar to that found in the control group (Supplementary Table S2)

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NADPH oxidases facilitate the transfer of electrons from NADPH to molecular oxygen, leading to the generation of the free radical superoxide and various downstream reactive oxygen species (ROS)