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The Brilliance of Borrelia: Mechanisms of Host Immune Evasion by Lyme Disease-Causing Spirochetes

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Indeed, a more systematic interaction between the clinical trial organizers and the regulatory authorities in terms of scientific advice or protocol assistance appears as the key to ameliorate the trial design by defining valid endpoints, the minimum number of patients to be enrolled, and the study format (e.g., placebo-controlled trial or N-of-1 trials)