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Polyphenols and flavonoids such as quercetin, kaempferol, luteolin, and apigenin not only inhibit pro-inflammatory cyclooxygenase-2 and lipoxygenase enzyme activities, but they also decrease NF-κB and AP-1 transcription factor activation, and regulate the NLRP3 inflammasome pathway (65)
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Study Design and Ethical Aspects The study was a randomized, placebo‐controlled, single‐blind clinical trial conducted at the Skin Research Center of Landproof Testing Technology Co
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