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Intriguingly, a preliminary in silico analysis of the 3′-UTR sequence of both DDO and DAO genes very recently disclosed the occurrence of several potential binding sites for microRNAs that are expressed in the CNS and that are known to bind sequences conserved in mammals ( Single Nucleotide Polymorphisms and Missense Variants In their study, the work of Usiello and his group proposed that two intronic SNPs within the human DDO gene, namely, rs2057149 (A/G) and rs3757351 (C/T), have a functional role in modulating hDASPO levels in the prefrontal cortex of healthy individuals ( DDO mRNA expression: the A and C alleles predict reduced transcription compared to the G and T alleles, respectively