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The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the iProx repository with the data set identifier (Project ID: IPX0016811000
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Doxepin is converted to the active metabolite desmethyldoxepin by N -demethylation and to other inactive metabolites in liver (Ziegler et al., 1978), and CYP2D6 and CYP2C19 are the main enzymes involved in this metabolism, with CYP1A2 and CYP2C9 involved to a lesser extent (Kirchheiner et al., 2002
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