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The oxidative stress index (OSI) was calculated using the following formula: The spectrophotometric measurement of paraoxonase (PON-1) activity was performed using a commercial PON-1 assay kit (RelAssay Diagnostics, Gaziantep, Turkey)
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In a separate study involving nine volunteers with GHD who were given higher MK-677 doses (50mg/daily), there were additional side effects noted, such as diarrhea and dry skin
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