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What Glutamine supplements can do According to a study published by the International Journal of Molecular Sciences, “In gut physiology, glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions.” The authors also note that: “As glutamine stores are depleted during severe metabolic stress including trauma, sepsis, and inflammatory bowel diseases, glutamine supplementation has been examined in patients to improve their clinical outcomes.” Naturally occurring glutamine in the body works to protect the intestine so it makes perfect sense that a supplement would also increase intestinal stability