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Metformin therapy may relieve the clinical symptoms of endometriosis (pelvic pain and menstrual disorders), accompanied by a reduction in the levels of inflammatory cytokines in the serum and peritoneal fluid in women with endometriosis due to its anti-inflammatory effects ( NF-κB has been extensively reported to play a role in the progression of endometriosis, particularly in lesion development, cell proliferation, and angiogenesis