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It has been reported that the K ox for a typical protein is ~1 (when 2GSH/GSSG is ~1) (Gilbert, ox of ~13 and therefore 50% of c-Jun is S-glutathionylated when 2GSH/GSSG is ~13 (Klatt et al., 1999)
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PF may exert antidepressant activity through a variety of mechanisms, such as preventing the overactivity of the HPA axis, regulating the monoaminergic nervous system, maintaining normal calcium homeostasis and calcium signaling pathway, inhibiting oxidative stress and apoptosis, and regulating the expression of neurotrophic factors in the brain (Figure 6)
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