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These enzymes interact with oxygen, other oxidants, and antioxidants (i.e., GSH is a substrate for glutathione peroxidase) to decrease the oxidative burden
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Additionally, mRNA expression of iron response element binding protein 2, encodes a master regulator of iron metabolism), and CS (citrate synthase, regulating the mitochondrial fatty acid metabolism) was upregulated in both models, while ACSF2 ((acyl-CoA synthetase family member 2, regulating the mitochondrial fatty acid metabolism) was upregulated only in APPswe/PS1dE9 mice
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