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Indeed, PKC inhibitors potentiate the antinociceptive effect of a single dose of morphine, indicating that PKC is involved in the tolerance that occurs during the single dose (Watkins et al., 1984
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10.1523/JNEUROSCI.3126-04.2004 [DOI] [PMC free article] [PubMed] [Google Scholar] Dutta R., Mcdonough J., Yin X., Peterson J., Chang A., Torres T., et al
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