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As a major methyl donor in cells, SAMe contributes to histone, DNA and RNA methylation and, therefore, to epigenetic regulation of gene expression ( Figure 1 Materials and Methods A full outline of Section “Materials and Methods” for this study can be found in previously published papers ( This study was approved by the Queen Elizabeth Hospital Research Ethics Committee (No: 2009139) and protocols and methods conformed to that committee’s regulatory standards
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Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling
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