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In the interest of using diverse stapling chemistries to sample different peptide conformations, as discussed previously by Kritzer and others, 452 DielsβAlder chemistry is well-suited for this application, as it can utilize a variety of diene and dienophile combinations and has already proved its value as a bioorthogonal, biostable conjugation chemistry
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Whether the arginate salt adds meaningfully to that existing tolerance is the open question
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