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Relevant issues can be addressed by exploring detoxification mechanisms, metabolic regulation, formulation approaches, and constructing PK/PD or PBPK models

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These results are supported by a recent randomized placebo controlled trial, which demonstrated that a 6-week sulforaphane intervention (30 mg/day) safely improved depressive symptoms, as measured by the Hamilton Rating Scale for Depression, in 66 participants with a history of a cardiac procedure and presence of mild to moderate depression (Ghazizadeh-Hashemi et al., 2021)