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decreased complex I activity is often observed in PD with lowered ATP production and elevated ROS formation (195)
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A further 10 drug categories were associated with at least 3 lead variants, including psychoactive drugs (muscle relaxants, psycholeptics, psychoanaleptics), treatments for metabolic syndrome and its comorbidities (diabetes drugs, lipid-modifying agents, reninβangiotensin agents) and immune modulators (anti-asthmatics, anti-histamines)
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