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Representative nanoengineering strategies include pH-responsive alginate coatings that co-encapsulate Escherichia coli Nissle 1917 (EcN) with 5-aminosalicylic acid, enabling simultaneous intestinal release of live bacteria and drug to modulate the microbiota, suppress pro-inflammatory cytokines, and repair the intestinal barrier (Peng et al., 2023)
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