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Single and/or complex antioxidant compounds targeting oxidative stress, redox metals, and neuronal cell death have been evaluated in multiple preclinical and clinical trials as a complementary therapeutic strategy for combating oxidative stress associated with neurodegenerative diseases
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recurrentis has developed at least two major strategies 7,8 : (i) antigenic variation of variable major proteins generating successive waves of antigenically distinct subpopulations under immune pressure, and (ii) complement evasion through recruitment of host-derived regulators such as factor H (FH), C4b-binding protein (C4BP), and C1 esterase inhibitor (C1-Inh), respectively 8
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