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l RENAL IMPAIRMENT g Use with caution in mild to moderate impairment (risk of toxicity including crystalluria)
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The basic reaction catalyzed by the cytochrome P450 is written as follows: NADPH + H + + O 2 + SH → NADP + + H 2 O + SOH By definition, the reaction is a monooxygenase because of the incorporation of only one of the two oxygen atoms onto the substrate
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