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Size:2mg Nasal Spray
The authors created an ARF6 mutant locked in its ADP-bound state to evaluate the effect on BACE1 and APP sorting, and found that it blocks the delivery of BACE1 to early endosomes, suggesting that the GTP hydrolysis of ARF6 is required for the sorting of BACE1 (Sannerud et al., 2011)
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